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After film critic Gene Siskel asked her, “What do you know for sure?” Oprah Winfrey began writing the “What I Know for Sure” column in O, The Oprah Magazine. Saying that the question offered her a way to take “stock of her life”, Oprah has penned one column a month over the last 14 years, years in which she retired The Oprah Winfrey Show (the highest-rated program of its kind in history), launched her own television network, became America’s only black billionaire, was awarded an honorary degree from Harvard University and the Presidential Medal of Freedom, watched friends and colleagues come and go, lost beloved pets and adopted new ones, and celebrated milestone birthdays. Throughout it all, she’s continued to offer her profound and inspiring words of wisdom in her “What I Know for Sure” column in O, The Oprah Magazine.